Dietary Exposure of Mink to Carp from Saginaw Bay.

Metadata:
Identification_Information:
Citation:
Citation_Information:
Originator:
Donald E. Tillitt, Robert W. Gale, John C. Meadows, James L. Zajicek, Paul H. Peterman; U.S. Geological Survey, Biological Resources Division
Originator: Silvia N. Heaton, Michigan State University
Originator: Paul D. Jones, ESR Environmental
Originator: Steven J. Bursian, Michigan State University
Originator: Timothy J. Kubiak, U.S. Fish and Wildlife Service
Originator:
John P. Giesy, Institute for Environmental Technology
Originator: Richard J. Aulerich, Michigan State University
Publication_Date: 1996
Title: Dietary Exposure of Mink to Carp from Saginaw Bay.
Publication_Information:
Publication_Place: Columbia, Missouri
Publisher:
U.S. Geological Survey, Biological Resources Division, Columbia Environmental Research Center (formerly National Biological Service)
Description:
Abstract:
In this study, mink (Mustela vison) were exposed to various amounts of carp (Cyprinus carpio) collected from Saginaw Bay, Lake Huron, MI, and the reproductive effects were observed. In this portion of the study, quantification of the dioxin-like activity was estimated by two different methods. One method was based on the relative potencies -Toxic Equivalency Factors (TEF) values- of individual Planar Halogenated Hydrocarbon (PHH) compounds and an additive model of toxicity to give toxic equivalents (TEQs). The other method utilized an in vitro bioasssay of the complex mixtures of PHHs found in the samples to directly quantify dioxin-like potency and is reported as tetrapchlorodibenzo-p-dioxin (TCDD)-EQ. This study was conducted to calibrate the HFIIE bioassay TCDD-EQ from an environmentally weathered PHH mixture to ecologically relevant end points in a sensitive species that occurs in the Great Lakes region.
Purpose:
The objectives of the present study were to (1) characterize the dietary exposure of the mink to PHHs; (2) compare an additive model of PHH toxicity (TEZs) with TCDD equivalents derived from the H4IIE bioassay (TCDD-EQs); (3) validate the use of the H4IIE boassay (TCDD-EQs); (4) assess the effect of these methods on the calculation of an estimated threshold dose (ETD) for reproductive toxicity in mink; and 4) determine biomagnification factors (BMFs) for PHHs from diets to mink livers which may be used in field risk assessments.
Time_Period_of_Content:
Time_Period_Information:
Single_Date/Time:
Calendar_Date: 19881202
Currentness_Reference: ground condition
Status:
Progress: Complete
Maintenance_and_Update_Frequency: None planned
Spatial_Domain:
Description_of_Geographic_Extent: Saginaw Bay near the mouth of the Saginaw River
Bounding_Coordinates:
West_Bounding_Coordinate: -84
East_Bounding_Coordinate: -83
North_Bounding_Coordinate: 44
South_Bounding_Coordinate: 43
Keywords:
Theme:
Theme_Keyword_Thesaurus: None
Theme_Keyword: planar halogenated hydrocarbons
Theme_Keyword: PCDDs
Theme_Keyword: polychlorinated dibenzofurans
Theme_Keyword: PCDFs
Theme_Keyword: 2,3,7,8-tetrachlorodibenzo-p-dioxin
Theme_Keyword: PHHs
Theme_Keyword: planar polychlorinated biphenyls
Theme_Keyword: pPCBs
Theme_Keyword: polychlorinated dibenzo-p-dioxins
Theme_Keyword: TCDD
Theme_Keyword: additive toxicity
Theme_Keyword: TEQs
Theme_Keyword: TCDD-EQs
Theme_Keyword:
consumptive normalized mink liver biomagnification factors
Theme_Keyword: BMFs
Place:
Place_Keyword_Thesaurus: None
Place_Keyword: Saginaw Bay, MI
Place_Keyword: Saginaw River
Place_Keyword: Michigan
Place_Keyword: MI
Taxonomy:
Taxonomic_Keywords: carp
Taxonomic_Keywords: mink
Taxonomic_Coverage:
Specific_Taxonomic_Information:
Kingdom: Animal
Division-Phylum: Chordata
Class: Mammalia
Order: Carnivora
Family: Mustelidae
Genus: Mustela
Species: Mustela vison
Applicable_Common_Names: mink
Taxonomic_Coverage:
Specific_Taxonomic_Information:
Kingdom: Animal
Division-Phylum: Chordata
Class: Actinopterygii
Order: Cypriniformes
Family: Cyprinidae
Genus: Cyprinus
Species: Cyprinus carpio
Applicable_Common_Names: carp
Access_Constraints: none
Use_Constraints: none
Point_of_Contact:
Contact_Information:
Contact_Organization_Primary:
Contact_Organization:
U.S. Geological Survey, Biological Resources
Division, Columbia Environmental Research Center
Contact_Person: Donald Tillitt
Contact_Address:
Address_Type: 4200 New Haven Road
City: Columbia
State_or_Province: Missouri
Postal_Code: 65201
Contact_Voice_Telephone: (573) 876-1886
Contact_Facsimile_Telephone: (573) 876-1896
Contact_Electronic_Mail_Address: Donald_Tillitt@usgs.gov
Cross_Reference:
Citation_Information:
Originator:
Donald E. Tillitt, Robert W. Gale, John C. Meadows, James L. Zajicek, Paul H. Peterman, Silvia N. Heaton, Paul D. Jones, Steven J. Bursian, Timothy J. Kubiak, John P. Giesy, and Richard J. Aulerich
Publication_Date: 1996
Title: Dietary exposure of mink to carp from Saginaw Bay.
Series_Information:
Series_Name: Environmental Science and Technology
Issue_Identification: Vol. 30, No. 1
Publication_Information:
Publication_Place: unknown
Publisher: American Chemical Society
Other_Citation_Details: pp. 283 - 291.
Data_Quality_Information:
Attribute_Accuracy:
Attribute_Accuracy_Report: unknown
Logical_Consistency_Report: not applicable
Completeness_Report: unknown
Lineage:
Methodology:
Methodology_Type: Field
Methodology_Identifier:
Methodology_Keyword_Thesaurus: None
Methodology_Keyword: mink exposure
Methodology_Description:
Carp were collected by electrofishing in Saginaw Bay, Michigan, near the mouth of the Saginaw River on December 2, 1988. Details of the preparation of diets and subsequent exposure of the mink were presented in Heaton et al. Briefly, dietary exposures were 0, 10, 20, or 40% ground, cooked, Saginaw Bay carp mixed into a standard mink ration and fed ad libitum. Each treatment group contained 3 males and 12 females. Dietary exposures began approximately 52 days prior to breeding and 104 days prior to whelping of the kits. Feed consumption and body weights of females were monitored weekly through the first 12 weeks of the trial. The study was continued until the kits were approximately 6 weeks old (day 182 of exposure), at which time all remaining adult female mink were euthanized and necropsied. Livers were subsampled for biochemical and chemical analysis.
Methodology_Citation:
Citation_Information:
Originator:
Heaton, S.N.; Bursian, S.J.; Giesy, J.P.; Tillitt, D.E.; Render, J.A.; Jones, P.D.; Berbugge, D.A.; Kubiak, T.J.; Aulerich, R.J.
Publication_Date: 1995
Title:
Dietary exposure of mink to carp from Saginaw Bay, Michigan. 1. Effects on reproduction and survival, and the potential risks to wild mink populations.
Series_Information:
Series_Name: Arch. Environ. Contam. Toxicol.
Issue_Identification: 28
Other_Citation_Details: p. 334-343
Methodology_Type: Lab
Methodology_Identifier:
Methodology_Keyword_Thesaurus: None
Methodology_Keyword: H4IIE Bioassay and TEFs
Methodology_Description:
Extracts of the composite diets and individual livers were prepared and tested with the H4IIE bioassay as previously described. H4IIE bioassay-derived TCDD equivalents (TCDD-EQ) were determined by comparison of ethoxyresorufin O-deethylase (EROD) induction in the extract-treated cells. The H4IIE TEF values are those derived from testing in the bioassay. The TEF values developed for risk assessment, international TEFs (I-TEFs), were arrived at through consensus of a wide variety of toxic end points and species. Concentrations of PHHs in the diets and livers of mink were multiplied by their TEF value (both H4IIE TEFs and I-TEFs were evaluated) to obtain TCDD equivalents (TEQs) from the chemical analysis. Concentrations less than detection limits were set to zero for the determination of TEQs.
Methodology_Citation:
Citation_Information:
Originator: Tillitt, D.E.; Giesy, J.P.; Ankley, G.T.
Publication_Date: 1991
Title: unknown
Series_Information:
Series_Name: Arch. Environ. Sci. Technol.
Issue_Identification: 25
Other_Citation_Details: p. 87
Methodology_Citation:
Citation_Information:
Originator:
Tillitt, D.E.; Kubiak, T.J. Ankley, G.T.; Giesy, J.P.
Publication_Date: 1993
Title:
Dioxin-like toxic potency in Forster's tern eggs from Green Bay, Lake Michigan, North America
Series_Information:
Series_Name: Chemosphere
Issue_Identification: 26
Other_Citation_Details: p. 2079-2084
Methodology_Citation:
Citation_Information:
Originator:
Tysklind, M.; Tillitt, D.; Eriksson, L.; Lundgren, K.; Rappe, C.
Publication_Date: 1994
Title:
A toxic equivalency factor scale for polychlorinated dibenzofurans
Series_Information:
Series_Name: Fundam. Appl. Toxicol.
Issue_Identification: 22
Other_Citation_Details: p. 277-285
Methodology_Citation:
Citation_Information:
Originator:
Ahlborg, U.G.; Brouwer, A.; Fingerhut, M.A.; Jacobson, J.L; Jacobson, S.W.; Kenedy, S.W.; Kettrup, A.A.F; Koeman, J.H>; Poiger, H.; Rappe, C.; Safe, S.H.; Seegal, R.F.; Tuomisto, J; van den Berg
Publication_Date: 1992
Title: Unknown
Series_Information:
Series_Name:
Eur. J. Pharmacol. Environ. Toxicol. Pharmacol. Sect.
Issue_Identification: 228
Other_Citation_Details: p. 179
Methodology_Citation:
Citation_Information:
Originator:
Ahlborg,U.G.; Becking, G.C.; Birnbaum, L.S.; Brouwer, A.; Derks, H.J.G.M.; Feeley, M.; Golor, G.; Hanberg, A.; Larsen, J. C.; Liem, A.K.D.; Safe, S.H.; Schlatter, C.; Waern, F.; Younes, M.; Yrjanheikki, E.
Publication_Date: 1994
Title: unknown
Series_Information:
Series_Name: Chemosphere
Issue_Identification: 28
Other_Citation_Details: p. 1049
Methodology_Type: Lab
Methodology_Identifier:
Methodology_Keyword_Thesaurus: None
Methodology_Keyword: chemical analysis
Methodology_Description:
Time-weighted composites of diets (based on the amount of time the mink were fed various batches of the diets) and composite samples of livers from adult females were analyzed for PCDDs, PCBs. Preparation of the samples included drying homogenates with sodium sulfate, extraction with dichloromethane, gravimetric lipid determination, reactive cleanup, gel permeation chromatography, and fractionation by carbon high pressure liquid chromatography (HPLC) as described previously (Feltz et al, 1995).
Methodology_Citation:
Citation_Information:
Originator:
Feltz, K.P.; Tillitt, D.E.; Gale, R.W.; Peterman, P.H.
Publication_Date: 1995
Title:
Automated HPLC fractionation of PCDDs and PCDFs and planar and nonplanar PCBs on C18-dispersed PX-21carbon.
Series_Information:
Series_Name: Environ. Sci. Technol.
Issue_Identification: 29
Other_Citation_Details: pp. 709-718.
Methodology_Type: Lab
Methodology_Identifier:
Methodology_Keyword_Thesaurus: None
Methodology_Keyword: chemical analysis
Methodology_Description:
The analytes were separated into four discrete fractions by dual HPLC columns of carbon dispersed on C18: (1) bulk and di-ortho-substituted PCBs; (2) non-ortho-substituted PCB's (3) PCDDs and PcDFs; and (4) mono-ortho-substituted PCBs (Feltz, et al 1995).
Methodology_Citation:
Citation_Information:
Originator:
Feltz, K.P.; Tillitt, D.E.; Gale, R.W.; Peterman, P.H.
Publication_Date: 1995
Title:
Automated HPLC fractionation of PCDDs and PCDFs and planar and nonplanar PCBs on C18-dispersed PX-21carbon.
Series_Information:
Series_Name: Environ. Sci. Technol.
Issue_Identification: 29
Other_Citation_Details: pp. 709-718.
Methodology_Type: Lab
Methodology_Identifier:
Methodology_Keyword_Thesaurus: None
Methodology_Keyword: chemical analysis
Methodology_Description:
Prior to extraction, each sample was spiked with 13C labeled recovery standards for the non-ortho-substituted PCBs, PCDDs, and PCDFs. Analytes in fractions 1 and 4 were determined by capillary gas chromatography (GC) with electron capture detection (GC-ECD, (Schwartz and Stalling, 1991) analytes in fraction 2 of the diets were determined by GC/high-resolution mass spectrometry (HRMS) by modifications of the methods of Kuehl et al while analytes in fraction 2 from the liver samples were analyzed by GC-ECD and analytes in fraction 3 were determined by low-resolution mass spectrometry (LRMS). Due to the large amounts of 2,3,4.7,8- pentachlorodibenofuran (2,3,4,7,8-PCDF) found in the diets and subsequently in the mink livers, confirmational analysis wsa performed by GC-LRMS using a 60 m x 250 micrometer SP-2331 capillary column based on its ability to completely resolve 2,3,3,7,8-PCDF from other penta-CDF congeners (Ryan et al, 1991).
Methodology_Citation:
Citation_Information:
Originator: Schwartz, T.R.; Stalling, D.L.
Publication_Date: 1991
Title:
Chemometric comparison of polychlorinated biphenyl residues and toxicologically active polychlorinated biphenyl congeners in the eggs of Forster's terns (Sterna fosteri)
Series_Information:
Series_Name: Arch. Environ. Contam. Toxicol.
Issue_Identification: 20
Other_Citation_Details: p. 183-199
Methodology_Citation:
Citation_Information:
Originator:
Kuehl, D.; Butterworth, B.C.; Libal, J.; Marquis, P.
Publication_Date: 1991
Title: unknown
Series_Information:
Series_Name: Chemosphere
Issue_Identification: 22
Other_Citation_Details: p. 849.
Methodology_Citation:
Citation_Information:
Originator:
Ryan, J.J.; Conacher, H.; Panopio, L; Lau, B.; Hardy, J.; Masuda, Y.
Publication_Date: Unknown
Title: Unknown
Series_Information:
Series_Name: J. Chromatogr.
Issue_Identification: 541
Other_Citation_Details: p. 131.
Methodology_Type: Lab
Methodology_Identifier:
Methodology_Keyword_Thesaurus: None
Methodology_Keyword: biomagnification factors
Methodology_Description:
Mink livers BMFs were determined for all PHHs base on lipid-normalized analyte concentrations.
Process_Step:
Process_Description:
Comparisons among treatment groups were made by one-way analysis of variance (ANOVA), and differences among treatment means and PHH concentrations in cooked and raw carp were tested with Tukey's test (p < 0.05)
Process_Date: 1995
Spatial_Data_Organization_Information:
Indirect_Spatial_Reference: Based on local reference names.
Entity_and_Attribute_Information:
Overview_Description:
Entity_and_Attribute_Overview:
Entity studied - mink (Mustela vison); Associated attribute - chemical characterization of diets and adult mink livers; comparison of an additive model of toxicity
Entity_and_Attribute_Detail_Citation: unknown
Distribution_Information:
Distributor:
Contact_Information:
Contact_Organization_Primary:
Contact_Organization:
U.S. Geological Survey, Biological Resources
Division, Columbia Environmental Research Center
Contact_Person: Christopher Henke
Contact_Position: Webmaster
Contact_Address:
Address_Type: mailing and physical address
Address: 4200 New Haven Rd
City: Columbia
State_or_Province: MO
Postal_Code: 65201
Contact_Voice_Telephone: 573-875-5399
Contact_Facsimile_Telephone: 573-876-1896
Contact_Electronic_Mail_Address: chris_henke@usgs.gov
Distribution_Liability:
Although these data have been processed successfully on a computer system at the U.S. Geological Survey, no warranty expressed or implied is made regarding the accuracy or utility of the data on any other system or for general or scientific purposes, nor shall the act of distribution constitute any such warranty. This disclaimer applies both to individual use of the data and aggregate use with other data. It is strongly recommended that these data are directly acquired from a U.S. Geological Survey server, and not indirectly through other sources which may have changed the data in some way. It is also strongly recommended that careful attention be paid to the contents of the metadata file associated with these data. The U.S. Geological Survey shall not be held liable for improper or incorrect use of the data described and/or contained herein.
Custom_Order_Process: Please contact distributor.
Metadata_Reference_Information:
Metadata_Date: 200004
Metadata_Contact:
Contact_Information:
Contact_Organization_Primary:
Contact_Organization:
Raytheon Information Technology and Scientific
Services (ITSS)
Contact_Person: Cheryl Solomon
Contact_Position: Ecosystem Coordinator
Contact_Address:
Address_Type: Mailing and Physical Address
Address: 4500 Forbes Boulevard
City: Lanham
State_or_Province: MD
Postal_Code: 20706
Country: USA
Contact_Voice_Telephone: 301 794-3049
Contact_Facsimile_Telephone: 301 794-3164
Contact_Electronic_Mail_Address: solomon@gcmd.nasa.gov
Metadata_Standard_Name:
NBII Content Standard for National Biological Information Infrastructure Metadata
Metadata_Standard_Version: December 1995
Metadata_Access_Constraints: None
Metadata_Use_Constraints: None
Generated by mp version 2.5.6 on Mon Jul 31 09:38:22 2000